PSVI-5 Treatment of Flunixin Meglumine and Prostaglandin E2 had no Effect on Corpora Lutea of Beef Cows

Abstract Flunixin meglumine (FM) is a COX enzyme inhibitor and prostaglandin E2 (PGE) builds the corpus luteum (CL). However, use of FM in conjunction with PGE has not been studied. The objective this study was to determine effects intravenous administration intravaginal release on characteristics CL concentrations progesterone blood. Beef cows (n = 24, divided between two replicants over time) were synchronized using Select Synch + CIDR protocol (expected estrus d 0). Cows randomly assigned one four treatment groups factorial arrangement, 6 each: Control, FM, PGE, or FM+PGE. Treatments administered from 13 19 (FM 2.2 mg/kg iv every 12 hr; released osmotic pump at 0.1 mL/d). Every other day 0 26, transrectal ultrasonography color Doppler used measure size blood perfusion CL; images later analyzed ImageJ. Blood samples collected via jugular venipuncture 26 for (P4; RIA) (ELISA). Data mixed procedure SAS 9.4 as repeated measure; significance declared when P ≤ 0.05. There no interactions thus main treatments evaluated. differences (P ≥ 0.164) size, vessel density, groups. 0.141) P4 density vessels decreased by 0.05). In conclusion, did influence nor circulation.